Welcome to the Pyle Lab

We explore RNA biology.

About

About the Pyle Lab

The Pyle Lab is located at Yale University, a long-standing hub of breakthroughs in the study of RNA. The Pyle Lab explores a diverse range of topics in RNA biology, studying the molecular interactions important for RNA function and the activities of RNA-protein machines. Using tools that range from cryo-EM to cell culture, we seek to understand the impact of RNA architecture and dynamics on the life of the cell. We are located in the award-winning Yale Science Building on Science Hill.

At the Bench

Outside Yale Science Building

Making Oligos on the Synthesizer

At the Bench

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Research Areas

Explore the Pyle Lab's research areas across many aspects of RNA biology, from fungal introns, to viral genomes, to the human immune system. Our most recent publications in each area will give a sense for the newest research directions in the lab.

Structure and Function of Large RNAs

Many cellular processes are catalyzed and regulated by large, highly structured RNA molecules.

Protein Machines on RNA Genes

Some of the most important motor proteins in our cells are nanomechanical enzymes that remodel or bind RNA.

RNA and Viruses

Structured RNA genomes are essential for the function of many viruses.

Drugging RNA

We are targeting RNA tertiary structures with small molecules in pathogenic organisms.

O. Fedorova & A.M. Pyle et al. ACS Chem Biol. 2023

L. Xu & A.M. Pyle et al. Nature. 2023

Image modified from James Yang. Based on:

N. Huston & A.M. Pyle et al. Mol Cell. 2021